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Article

Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages.

Investigative ophthalmology & visual science - 1 Dec 2016

Collery Ross F, Volberding Peter J, Bostrom Jonathan R, Link Brian A, Besharse Joseph C

Abstract excerpt

Purpose: Mutations in membrane frizzled-related protein (MFRP) are associated with nanophthalmia, hyperopia, foveoschisis, irregular patches of RPE atrophy, and optic disc drusen in humans. Mouse mfrp mutants show retinal degeneration but no change in eye size or refractive state. The goal of this work was to generate zebrafish mutants to investigate the loss of Mfrp on eye size and refractive state, and to...

Read the complete abstract on PubMed

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Share to Glycoproteins
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Microphthalmos

Share to Retinal Degeneration

Share to Retinal Pigment Epithelium

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Source

Open in PubMed Open full text

Identifiers

PMID: 28002843
DOI: 10.1167/iovs.16-19593
PMCID: PMC5215506

Genes

RPE
MFRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages.PMID 28002843Read ↗

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