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Article

Unveiling ZNF124 as a novel determinant in neurodegeneration: orchestration of photoreceptor homeostasis through MSX2 transcriptional regulation.

Cell death & disease - 19 Feb 2026

Yang Yeming, Jiang Xiaoyan, Li Shujin, Sun Kuanxiang, Zou Rong, Chen Can, Shi Yi, Liu Wenjing, Sundaresan Periasamy, Huang Lulin, Zhang Lin, Yang Zhenglin, Zhu Xianjun

Abstract excerpt

Retinitis pigmentosa (RP), affecting more than 20 million people worldwide, refers to a group of inherited retinal dystrophies characterized by progressive photoreceptor degeneration and vision loss. However, the underlying genetic causes of substantial RP cases remain unidentified. In this report, we identified a novel homozygous splicing variant, c.219-1delG, which introduced skipping of exon 4 of the ZNF124...

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Source

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Identifiers

PMID: 41708596
DOI: 10.1038/s41419-026-08487-6
PMCID: PMC12949019

Genes

ZNF124
MSX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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