Article

Kinetic modeling of ImmunoPET enables in vivo quantification of EGFRvIII expression in glioblastoma

2026-04-20

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) remains the most lethal primary brain tumour in adults. Targeted strategies against epidermal growth factor receptor variant III (EGFRvIII), a tumour-specific mutation expressed in GBM, are advancing clinically; however, their success depends on accurate, non-invasive assessment of EGFRvIII-expression for patient selection. Here, we develop and validate an immuno-Posi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 338bf7b5-cf7a-5377-b4ea-6a9016db99e2
DOI: 10.21203/rs.3.rs-9177895/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Kinetic modeling of ImmunoPET enables in vivo quantification of EGFRvIII expression in glioblastomaDOI 10.21203/rs.3.rs-9177895/v1Read

In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature.Semantic proximity Read

Personalized Glioblastoma Multiforme Growth Modeling by Integrating Clinical Genomic and Phenotypic DataSemantic proximity Read

In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ-Index.Semantic proximity Read

Transport vehicle–mediated TREM2 PET maps myeloid cells in the glioblastoma microenvironmentSemantic proximity Read

Radiolabeled novel mAb 4G1 for immunoSPECT imaging of EGFRvIII expression in preclinical glioblastoma xenografts.Semantic proximity Read

Dynamic 18F-FDopa PET Imaging for Newly-diagnosed Gliomas: Is a Semi-quantitative Model Sufficient?Semantic proximity Read

A 68Ga–BCMA Ectodomain Tracer Enables PET/MR Longitudinal Tracking of Clinical-Grade BCMA/CD19 CAR T CellsSemantic proximity Read

MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model.Semantic proximity Read

Use of magnetic perfusion-weighted imaging to determine epidermal growth factor receptor variant III expression in glioblastoma.Semantic proximity Read

The prognostic significance of TSPO-PET imaging in IDH-mutant glioma: a single-center, retrospective study.Semantic proximity Read

Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8βSemantic proximity Read

Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma.Semantic proximity Read