Article
In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature.
Neuro-oncology - 5 Jul 2018
Akbari Hamed, Bakas Spyridon, Pisapia Jared M, Nasrallah MacLean P, Rozycki Martin, Martinez-Lage Maria, Morrissette Jennifer J D, Dahmane Nadia, O'Rourke Donald M, Davatzikos Christos
Abstract excerpt
Background: Epidermal growth factor receptor variant III (EGFRvIII) is a driver mutation and potential therapeutic target in glioblastoma. Non-invasive in vivo EGFRvIII determination, using clinically acquired multiparametric MRI sequences, could assist in assessing spatial heterogeneity related to EGFRvIII, currently not captured via single-specimen analyses. We hypothesize that integration of subtle, yet...
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