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Article

In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ-Index.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2017

Bakas Spyridon, Akbari Hamed, Pisapia Jared, Martinez-Lage Maria, Rozycki Martin, Rathore Saima, Dahmane Nadia, O'Rourke Donald M, Davatzikos Christos

Abstract excerpt

Purpose: The epidermal growth factor receptor variant III (EGFRvIII) mutation has been considered a driver mutation and therapeutic target in glioblastoma, the most common and aggressive brain cancer. Currently, detecting EGFRvIII requires postoperative tissue analyses, which are ex vivo and unable to capture the tumor's spatial heterogeneity. Considering the increasing evidence of in vivo imaging signatures...

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Identifiers

PMID: 28428190
DOI: 10.1158/1078-0432.CCR-16-1871
PMCID: PMC5559313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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