Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma.

Cancer research - 15 Mar 2011

Shazeeb Mohammed S, Sotak Christopher H, DeLeo Michael, Bogdanov Alexei

Abstract excerpt

Epidermal growth factor receptor (EGFR) imaging in brain tumors is essential to visualize overexpression of EGFRvIII variants as a signature of highly aggressive gliomas and to identify patients that would benefit from anti-EGFR therapy. Seeking imaging improvements, we tested a novel pretargetin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Humanized
Share to Glioma
Share to Horseradish Peroxidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Image Enhancement

Share to Neoplasm Transplantation

Share to Rats, Nude

Share to Signal Processing, Computer-Assisted

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 21245103
DOI: 10.1158/0008-5472.CAN-10-1139
PMCID: PMC3059397

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21245103-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma.PMID 21245103Read ↗

MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model.Semantic proximity Read ↗

Kinetic modeling of ImmunoPET enables in vivo quantification of EGFRvIII expression in glioblastomaSemantic proximity Read ↗

Antigen-dependent inducible T cell reporter system for PET imaging of breast cancer and glioblastomaSemantic proximity Read ↗

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastomaSemantic proximity Read ↗

Targeting EGFR in glioblastoma with a novel brain-penetrant small molecule EGFR-TKISemantic proximity Read ↗

89Zr-cetuximab PET imaging in patients with advanced colorectal cancer.Semantic proximity Read ↗

Pharmacokinetic analysis of 6-O-[18F]FEE for PET imaging of EGFR mutation.Semantic proximity Read ↗

DCE-MRI detects OATP-expressing transplanted cells using clinical doses of gadolinium contrast agentSemantic proximity Read ↗

Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with <i>in vivo</i> magnetic resonance spectroscopySemantic proximity Read ↗

Hemodynamic molecular imaging of tumor-associated enzyme activity in the living brainSemantic proximity Read ↗

Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.