Article

High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes

2016-09-19

Abstract excerpt

Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is a main challenge for precision medicine. Here we propose a new method that models cell signaling using biological knowledge on signal transduction. The method recodes individual gene expression values (and/or gene mutations) into accurate measurements of changes in the activity of signaling circuits, which ult...

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Identifiers and source

Literature Corpus work: 33891ac8-8a9d-507f-a572-cfbebde19082
DOI: 10.1101/076083

Open publication

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