Article
High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes.
Oncotarget - 17 Jan 2017
Hidalgo Marta R, Cubuk Cankut, Amadoz Alicia, Salavert Francisco, Carbonell-Caballero José, Dopazo Joaquin
Abstract excerpt
Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is a main challenge for precision medicine. Here we propose a new method that models cell signaling using biological knowledge on signal transduction. The method recodes individual gene expression values (and/or gene mutations) into accurate measurements of changes in the activity of signaling circuits, which...
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