Article

Accurately estimating pathway activity in single cells for clustering and differential analysis

2023-03-27

Abstract excerpt

Inferring which and how biological pathways and gene sets are changing is a key question in many studies that utilize single-cell RNA sequencing. Typically, these questions are addressed by quantifying the enrichment of known gene sets in lists of genes derived from global analysis. Here we offer SiPSiC, a new method to infer pathway activity in each cell. This allows more sensitive differential analysis and utili...

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Literature Corpus work: 79f95ff0-c0aa-5f36-b362-2cb4244c048a
DOI: 10.1101/2023.03.27.534310

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