Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathway reporter genes define molecular phenotypes of human cells.

BMC genomics - 24 Apr 2015

Zhang Jitao David, Küng Erich, Boess Franziska, Certa Ulrich, Ebeling Martin

Abstract excerpt

BACKGROUND: The phenotype of a living cell is determined by its pattern of active signaling networks, giving rise to a "molecular phenotype" associated with differential gene expression. Digital amplicon based RNA quantification by sequencing is a useful technology for molecular phenotyping as a novel tool to characterize the state of biological systems. RESULTS: We show here that the activity of signaling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Induced Pluripotent Stem Cells

Share to Metabolic Networks and Pathways

Share to Myocytes, Cardiac

Share to Principal Component Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 25903797
DOI: 10.1186/s12864-015-1532-2
PMCID: PMC4415216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathway reporter genes define molecular phenotypes of human cells.PMID 25903797Read ↗

Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytesSemantic proximity Read ↗

High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes.Semantic proximity Read ↗

High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomesSemantic proximity Read ↗

Single-Cell RNA-Sequencing and Optical Electrophysiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Discordance Between Cardiac Subtype-Associated Gene Expression Patterns and Electrophysiological PhenotypesSemantic proximity Read ↗

Noori T, Rudd-Schmidt JA, Kane A, et al. A cell-based functional assay that accurately links genotype to phenotype in familial HLH. Blood. 2023;141(19):2330-2342.Semantic proximity Read ↗

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failureSemantic proximity Read ↗

Predicting mechanism of action of cellular perturbations with pathway activity signaturesSemantic proximity Read ↗

Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patientsSemantic proximity Read ↗

RAStoERK: a reference interaction atlas for insights into signaling and diseaseSemantic proximity Read ↗

A single-cell CRISPRi platform for characterizing candidate genes relevant to metabolic disorders in human adipocytesSemantic proximity Read ↗

Single Cell Transcriptomic Analysis in a Mouse Model of Barth Syndrome Reveals Cell-Specific Alterations in Gene Expression and Intercellular CommunicationSemantic proximity Read ↗

TRANSPATH: an information resource for storing and visualizing signaling pathways and their pathological aberrations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.