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Article

Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape.

Nature communications - 23 Jul 2024

Wu Xinyu, Go Margareta, Nguyen Julie V, Kuchel Nathan W, Lu Bernadine G C, Zeglinski Kathleen, Lowes Kym N, Calleja Dale J, Mitchell Jeffrey P, Lessene Guillaume, Komander David, Call Matthew E, Call Melissa J

Abstract excerpt

Papain-like protease (PLpro) is an attractive drug target for SARS-CoV-2 because it is essential for viral replication, cleaving viral poly-proteins pp1a and pp1ab, and has de-ubiquitylation and de-ISGylation activities, affecting innate immune responses. We employ Deep Mutational Scanning to evaluate the mutational effects on PLpro enzymatic activity and protein stability in mammalian cells. We confirm features...

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Identifiers

PMID: 39043718
DOI: 10.1038/s41467-024-50566-9
PMCID: PMC11266423

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