Article

GLproxScape reconstructs spatial chromatin occupancy landscapes from tiled genomic locus proteomics

2026-07-03

Abstract excerpt

Genomic locus proteomics combines proximity labeling with mass spectrometry to identify the proteins associated with user-defined genomic loci. However, per-region enrichment values from tiled guide designs are typically pooled before hit calling, collapsing the latent spatial structure encoded by overlapping measurements. Here, we describe GLproxScape, an R package that treats per-region enrichments as indirect s...

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Literature Corpus work: 3380d5b0-99c7-58f1-9498-5aae80469bb6
DOI: 10.64898/2026.06.29.735243

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