Article

An organoid CRISPRi screen revealed that SOX9 primes human fetal lung tip progenitors to receive WNT and RTK signals

2022-01-27

Abstract excerpt

<h4>ABSTRACT</h4> The balance between self-renewal and differentiation in human fetal lung epithelial progenitors controls the size and function of the adult organ. Moreover, progenitor cell gene regulation networks are employed by both regenerating and malignant lung cells, where modulators of their effects could potentially be of therapeutic value. Details of the molecular networks controlling human lung progen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 33628b70-8fd3-5653-a4a7-2302ac5ea8d4
DOI: 10.1101/2022.01.27.478034

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An organoid CRISPRi screen revealed that SOX9 primes human fetal lung tip progenitors to receive WNT and RTK signalsDOI 10.1101/2022.01.27.478034Read

SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signallingSemantic proximity Read

Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticitySemantic proximity Read

<i>In vitro</i> induction and <i>in vivo</i> engraftment of lung bud tip progenitor cells derived from human pluripotent stem cellsSemantic proximity Read

Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticitySemantic proximity Read

Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regenerationSemantic proximity Read

Basal stem cell fate specification is mediated by SMAD signaling in the developing human lungSemantic proximity Read

Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory diseaseSemantic proximity Read

A spatially-resolved blueprint of the developing human lung reveals a WNT-driven niche for basal stem cellsSemantic proximity Read

Single-cell time-series mapping of cell fate trajectories reveals an expanded developmental potential for human PSC-derived distal lung progenitorsSemantic proximity Read

Human alveolar progenitors generate dual lineage bronchioalveolar organoidsSemantic proximity Read

Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticitySemantic proximity Read

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoidsSemantic proximity Read