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Article

Human alveolar progenitors generate dual lineage bronchioalveolar organoids

25 Aug 2022

Abstract excerpt

Abstract Mechanisms of epithelial renewal in the alveolar compartment remain incompletely understood. To this end, we aimed to characterize alveolar progenitors. Single-cell RNA-sequencing (scRNA-seq) analysis of the HTII-280 + /EpCAM + population from adult human lung revealed subclusters enriched for adult stem cell signature (ASCS) genes. We found that alveolar progenitors in organoid culture in vitro show...

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PMID: 36008580
DOI: 10.1038/s42003-022-03828-5

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