Article

Detecting domain-level organization in genome-wide association study summary statistics using frequency–impact–reliability profiles

2026-07-06

Abstract excerpt

Genome-wide association studies (GWAS) identify trait-associated variants but are typically interpreted through single-variant significance and locus-level peaks, treating summary statistics as collections of independent signals. Here we show that GWAS summary statistics exhibit previously unrecognized local genetic–statistical organization along genomic coordinates. We develop FIR-GWAS, a framework that integrate...

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Literature Corpus work: 334d9587-9b12-58a8-976c-d68a627ad282
DOI: 10.64898/2026.07.01.735858

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