Article

Exogenous DNA upregulates DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway

2022-05-14

Abstract excerpt

Pro-inflammatory cytokines upregulate the expression of the H 2 O 2 -producing NADPH oxidase dual oxidase 2 (DUOX2) which, when elevated, adversely affects survival from pancreatic ductal adenocarcinoma (PDAC). Because the cGAS-STING pathway is known to initiate pro-inflammatory cytokine expression following uptake of exogenous DNA, we examined whether activation of cGAS-STING could play a role in the generation...

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Literature Corpus work: 33338d1b-bfb9-52d5-aaeb-7f39d2debe77
DOI: 10.1101/2022.05.14.491678

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