Article

Extensive and Persistent Extravascular Dermal Fibrin Deposition Characterizes Systemic Sclerosis

2023-01-19

Abstract excerpt

Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive multiorgan fibrosis. While the cause of SSc remains unknown, a perturbed vasculature is considered a critical early step in the pathogenesis. Using fibrinogen as a marker of vascular leakage, we found extensive extravascular fibrinogen deposition in the dermis of both limited and diffuse systemic sclerosis disease, and it was present in...

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Literature Corpus work: 332c7db4-4e18-564d-848b-64e8a642c1c1
DOI: 10.1101/2023.01.16.523256

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