Article

Patient-derived vascularized skin organoids unravel the role of systemic sclerosis fibroblasts in microvascular dysfunction

2025-12-03

Abstract excerpt

Systemic sclerosis (SSc) is a complex connective tissue disease characterized by excessive extracellular matrix deposition and endothelial dysfunction leading to skin fibrosis and vascular complications. To investigate the contribution of fibroblasts to SSc-associated vasculopathy, we generated 3D vascularized skin organoids incorporating patient-derived fibroblasts and healthy endothelial cells. Comparative analy...

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Literature Corpus work: ded36993-af75-5315-8e2a-0e3f5aeb5928
DOI: 10.64898/2025.12.03.691822

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