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Article

The Ischemic Switch: From Raynaud’s to Autoallergic Mast Cell-Driven Vasculopathy in Systemic Sclerosis

2026-06-24

Abstract excerpt

Raynaud’s Phenomenon (RP) serves as the clinical sentinel for systemic autoimmunity, frequently predating connective tissue disease (CTD) diagnosis by years. While RP is a largely benign functional vasospasm in the general population, its prevalence in Systemic Sclerosis (SSc) approaches 99%. A fundamental mystery in rheumatology is the divergent fate of the microvasculature across CTDs. While RP can occur in othe...

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Literature Corpus work
d06aa1cc-11bd-591f-85b8-f16dd39174ed
DOI
10.20944/preprints202606.1782.v1
Open publication

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