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Article

Systemic sclerosis: current views of its pathogenesis.

Autoimmunity reviews - 1 Jun 2003

Derk Chris T, Jimenez Sergio A

Abstract excerpt

Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the microvasculature, and numerous cellular and humoral immune abnormalities. Clinically, SSc is very heterogeneous, encompassing a spectrum ranging from mild limited forms of skin sclerosis with minimal internal organ involvement to severe...

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PMID: 12848944
DOI: 10.1016/s1568-9972(03)00005-3

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