Article

Human blood vessel organoids recapitulate key mechanisms of transition from vasculopathy to fibrosis in systemic sclerosis

2025-04-05

Abstract excerpt

<h4>Summary</h4> Systemic sclerosis (SSc) is an autoimmune disease that transitions from vasculopathy as an initiating pathogenic event to tissue fibrosis. The mechanisms of these transitions remain, however, poorly understood, mainly because complex multicellular human models of SSc vasculopathy are lacking. Here we characterized blood vessel organoids (BVOs) as a novel model system of vasculopathy in SSc. We de...

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Literature Corpus work: ea11b966-84e7-5a0e-b2ca-66d1c96f0db7
DOI: 10.1101/2025.03.31.646441

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