Article

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency

2020-10-27

Abstract excerpt

<h4>Summary</h4> Loss of the ataxia-telangiectasia mutated (ATM) kinase causes cerebellum-specific neurodegeneration in humans. We previously demonstrated that deficiency in ATM activation via oxidative stress generates high levels of insoluble protein aggregates in human cells, reminiscent of protein dysfunction in common neurodegenerative disorders. Here we show that this process is driven by poly-ADP-ribose po...

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Literature Corpus work: 5e64b397-8c6c-5d02-8541-aa5ae7693abc
DOI: 10.1101/2020.10.27.357210

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