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Article

Phenotypes and cytokines of NK cells in triple-negative breast cancer resistant to checkpoint blockade immunotherapy.

Breast cancer research : BCR - 3 Apr 2025

Wang Youlong, Jiang Yongluo, Ding Fadian, Lu Jun, Huang Tong, Zhong Guanqing, Zhu Pengfei, Ma Yue, Li Jin, Wang Xinjia, Lin Jiacai, Zheng Hongjun, Wang Weidong, Xu Yiwei, Lyu Xiajie, Niu Yu Si, Qi Xin, Li Jinjian, Chen Bocen, He Tingting, Zeng Jiling, Ma Yifei

Abstract excerpt

Neoadjuvant checkpoint blockade immunotherapy (NATI) significantly prolonged outcomes for triple-negative breast cancer (TNBC). Residual tumor cells that survive NATI represent high-risk cell populations with metastatic potential and usually evade immunosurveillance by NK cells. Using an 82-protein panel, we here profiled single-cell membrane proteomics of CD56+ (NCAM1+) NK cells from tumor, peri-cancerous...

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Identifiers

PMID: 40181426
DOI: 10.1186/s13058-025-02003-y
PMCID: PMC11969778

Genes

SELL
IL10
NCAM1

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