Article

Both vascular risk factors and common genetic variants influence penetrance of variants causing monogenic stroke

2022-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Monogenic forms of stroke have been thought to be rare with high penetrance. However, recent studies have reported typical monogenic stroke pathogenic variants are much commoner than expected in the general population. Whether such variants are associated with disease, and why the phenotype of these variants varies so widely remain unclear. In 454,787 individuals in UK Biobank, we identified typi...

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Literature Corpus work: eaba1ae2-5b27-5980-a96b-8965022ccf0a
DOI: 10.1101/2022.05.24.22275509

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