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Gut dysbiosis and homocysteine: a couple for boosting neurotoxicity in Huntington disease

12 Apr 2022

Abstract excerpt

Abstract Huntington’s disease (HD), a neurodegenerative disorder caused by an expansion of the huntingtin triplet (Htt), is clinically characterized by cognitive and neuropsychiatric alterations. Although these alterations appear to be related to mutant Htt (mHtt)-induced neurotoxicity, several other factors are involved. The gut microbiota is a known modulator of brain-gut communication and when altered...

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PMID: 35411760
DOI: 10.1515/revneuro-2021-0164

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