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Gut Microbiota as a Modifier of Huntington’s Disease Pathogenesis

10 May 2024

Abstract excerpt

Huntingtin (HTT) protein is expressed in most cell lineages, and the toxicity of mutant HTT in multiple organs may contribute to the neurological and psychiatric symptoms observed in Huntington's disease (HD). The proteostasis and neurotoxicity of mutant HTT are influenced by the intracellular milieu and responses to environmental signals. Recent research has highlighted a prominent role of gut microbiota in...

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PMID: 38728199
DOI: 10.3233/jhd-240012

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