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Targeting apoptotic pathways for cancer therapy

14 Jul 2024

Abstract excerpt

Apoptosis is a form of programmed cell death that is mediated by intrinsic and extrinsic pathways. Dysregulation of and resistance to cell death are hallmarks of cancer. For over three decades, the development of therapies to promote treatment of cancer by inducing various cell death modalities, including apoptosis, has been a main goal of clinical oncology. Apoptosis pathways also interact with other signaling...

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PMID: 39007268
DOI: 10.1172/jci179570

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