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Article

Mitochondrial diabetes and its lessons for common Type 2 diabetes.

Biochemical Society transactions - 1 Nov 2006

Maassen J A, 't Hart L M, Janssen G M C, Reiling E, Romijn J A, Lemkes H H

Abstract excerpt

Multiple pathogenic pathways are able to deregulate glucose homoeostasis leading to diabetes. The 3243A>G mutation in the mtDNA (mitochondrial DNA)-encoded tRNALeu,UUR gene was found by us to be associated with a particular diabetic subtype, designated MIDD (maternally inherited diabetes and deafness). This mutation causes an imbalance in the mitochondrion between proteins encoded by the nuclear and mitochondrial...

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Share to Diabetes Mellitus, Type 2
Share to DNA, Mitochondrial
Share to Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin-Secreting Cells

Share to Mitochondria

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 17052206
DOI: 10.1042/BST0340819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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