Article
Insulin Resistance in Mitochondrial Diabetes.
Biomolecules - 7 Jan 2023
Takano Chika, Ogawa Erika, Hayakawa Satoshi
Abstract excerpt
Mitochondrial diabetes (MD) is generally classified as a genetic defect of β-cells. The main pathophysiology is insulin secretion failure in pancreatic β-cells due to impaired mitochondrial ATP production. However, several reports have mentioned the presence of insulin resistance (IR) as a clinical feature of MD. As mitochondrial dysfunction is one of the important factors causing IR, we need to focus on IR as...
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