Article

Early diagnosis of leptomeningeal disease in diffuse midline gliomas by detection of H3F3A K27M mutation in circulating tumor DNA of cerebrospinal fluid

2024-10-07

Abstract excerpt

<h4>Introduction: </h4> Leptomeningeal disease (LMD) in diffuse midline gliomas can lead to devastating symptoms such as severe pain, urinary incontinence, and tetraparesis, with limited treatment options. In the present study, we determined whether the detection of H3F3A K27M-mutant droplets in cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) could serve as a reliable biomarker for the detection of LMD in...

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Literature Corpus work: 32b60035-18ac-59f8-929a-844891e6b09e
DOI: 10.22541/au.172829535.51286862/v1

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