Article
Liquid Biopsy of Cerebrospinal Fluid Enables Selective Profiling of Glioma Molecular Subtypes at First Clinical Presentation.
Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Apr 2023
Orzan Francesca, De Bacco Francesca, Lazzarini Elisabetta, Crisafulli Giovanni, Gasparini Alessandra, Dipasquale Angelo, Barault Ludovic, Macagno Marco, Persico Pasquale, Pessina Federico, Bono Beatrice, Giordano Laura, Zeppa Pietro, Melcarne Antonio, Cassoni Paola, Garbossa Diego, Santoro Armando, Comoglio Paolo M, Indraccolo Stefano, Simonelli Matteo, Boccaccio Carla
Abstract excerpt
PURPOSE: Current glioma diagnostic guidelines call for molecular profiling to stratify patients into prognostic and treatment subgroups. In case the tumor tissue is inaccessible, cerebrospinal fluid (CSF) has been proposed as a reliable tumor DNA source for liquid biopsy. We prospectively investigated the use of CSF for molecular characterization of newly diagnosed gliomas. EXPERIMENTAL DESIGN: We recruited two...
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