Article

Investigating the effects of prednisolone on behavior in mouse models of Duchenne muscular dystrophy

2024-10-29

Abstract excerpt

<h4>Background</h4> Next to progressive muscle loss, Duchenne muscular dystrophy patients suffer from behavioral and cognitive problems. This is due to mutations in the DMD gene, that result in the lack of dystrophin in both the muscles and brain. As part of the standards of care, patients receive corticosteroids (prednisolone or deflazacort) to slow down muscle degeneration. The precise consequences of chronic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 32857e5a-627c-586f-816b-ec15bc975fdb
DOI: 10.1101/2024.10.29.620838

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigating the effects of prednisolone on behavior in mouse models of Duchenne muscular dystrophyDOI 10.1101/2024.10.29.620838Read

Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibitionSemantic proximity Read

Assessment of Behavioral Characteristics With Procedures of Minimal Human Interference in the mdx Mouse Model for Duchenne Muscular DystrophySemantic proximity Read

Prednisolone rescues Duchenne Muscular Dystrophy phenotypes in human pluripotent stem cells-derived skeletal muscle <i>in vitro</i>Semantic proximity Read

Cognitive flexibility deficits in a mouse model for the absence of full‐length dystrophinSemantic proximity Read

Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell-derived skeletal muscle in vitro.Semantic proximity Read

The glucocorticoid receptor acts locally to protect dystrophic muscle and heart during disease.Semantic proximity Read

Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans.Semantic proximity Read

Impact of distinct dystrophin gene mutations on behavioral phenotypes of Duchenne muscular dystrophy.Semantic proximity Read

Pregnancy-induced amelioration of muscular dystrophy phenotype in mdx mice via muscle membrane stabilization effect of glucocorticoid.Semantic proximity Read

Co-administration of deflazacort and doxycycline: a potential pharmacotherapy for Duchenne muscular dystrophy.Semantic proximity Read

Learning, memory and blood–brain barrier pathology in Duchenne muscular dystrophy mice lacking Dp427, or Dp427 and Dp140Semantic proximity Read

Glucocorticoid Steroid and Alendronate Treatment Alleviates Dystrophic Phenotype with Enhanced Functional Glycosylation of α-Dystroglycan in Mouse Model of Limb-Girdle Muscular Dystrophy with FKRPP448L Mutation.Semantic proximity Read