Article
Pregnancy-induced amelioration of muscular dystrophy phenotype in mdx mice via muscle membrane stabilization effect of glucocorticoid.
PloS one - 1 Jan 2015
Shimizu-Motohashi Yuko, Asakura Yoko, Motohashi Norio, Belur Nandkishore R, Baumrucker Michael G, Asakura Atsushi
Abstract excerpt
Duchenne muscular dystrophy (DMD), the most common and severe type of dystrophinopathy, is an X-linked recessive genetic disease caused by the absence of dystrophin, which leads to fragility and vulnerability of the sarcolemma to mechanical stretching with increased membrane permeability. Currently, glucocorticoids such as prednisolone are the only medication available for DMD. However, molecular pathways...
Topics
- Animals
- Annexin A1
- Cell Membrane
- Cell Membrane Permeability
- Corticosterone
- Female
- Mice
- Mice, Inbred mdx
- Muscle Fibers, Skeletal
- Muscular Dystrophy, Duchenne
- Osmotic Pressure