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Article

Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

1 Apr 2021

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (FACT), a chromatin remodeling complex involved in transcription, replication, and DNA repair. We show that CBL0137 displays profound cytotoxic activity against a panel of...

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Share to Epigenetics and DNA Methylation
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PMID: 33852836
DOI: 10.1016/j.celrep.2021.108994

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