Article
Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.
Molecular cancer research : MCR - 1 Jul 2020
Wang Zhaohui, Xu Cheng, Diplas Bill H, Moure Casey J, Chen Chin-Pu Jason, Chen Lee H, Du Changzheng, Zhu Huishan, Greer Paula K, Zhang Liwei, He Yiping, Waitkus Matthew S, Yan Hai
Abstract excerpt
Diffuse intrinsic pontine glioma (DIPG) is an invariably fatal brain tumor occurring predominantly in children. Up to 90% of pediatric DIPGs harbor a somatic heterozygous mutation resulting in the replacement of lysine 27 with methionine (K27M) in genes encoding histone H3.3 (H3F3A, 65%) or H3.1 (HIST1H3B, 25%). Several studies have also identified recurrent truncating mutations in the gene encoding protein...
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