Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maturation of human cardiac organoids enables complex disease modeling and drug discovery

25 Jun 2025

Abstract excerpt

Maturation of human pluripotent stem (hPS) cell-derived cardiomyocytes is critical for their use as a model system. Here we mimic human heart maturation pathways in the setting of hPS cell-derived cardiac organoids (hCOs). Specifically, transient activation of 5' AMP-activated protein kinase and estrogen-related receptor enhanced cardiomyocyte maturation, inducing expression of mature sarcomeric and oxidative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Pluripotent Stem Cells Research
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40562874
DOI: 10.1038/s44161-025-00669-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maturation of human cardiac organoids enables complex disease modeling and drug discoveryPMID 40562874Read ↗

Maturation of human cardiac organoids enables complex disease modelling and drug discoverySemantic proximity Read ↗

Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseasesSemantic proximity Read ↗

Enhanced iPSC Cardiomyocyte Maturation via Combined 3D-Culture and Metabolic CuesSemantic proximity Read ↗

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart DiseaseSemantic proximity Read ↗

Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production.Semantic proximity Read ↗

Generation of human chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseasesSemantic proximity Read ↗

Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytesSemantic proximity Read ↗

Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes: a Critical Step for Drug Development and Cell Therapy.Semantic proximity Read ↗

Maturation-Based Model of Arrhythmogenic Right Ventricular Dysplasia Using Patient-Specific Induced Pluripotent Stem Cells.Semantic proximity Read ↗

Human Cardiac Organoids for Disease ModelingSemantic proximity Read ↗

Industrialization of three-dimensional hiPSC-cardiac microtissues for high-throughput cardiac safety and drug discovery screeningSemantic proximity Read ↗

Human Pluripotent Stem Cell-Derived Cardiac Cells: Application in Disease Modeling, Cell Therapy, and Drug DiscoverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.