Mendelian randomization identifies 1400 metabolites that may be pathogenic candidates for non-alcoholic fatty liver disease

Abstract excerpt

The observational association between circulating metabolites and non-alcoholic fatty liver disease (NAFLD) has been somewhat demonstrated. However, it is unclear whether there is a causal relationship for this association. In this study, we used a two-sample bidirectional MR analysis approach to assess the association between 1,400 blood metabolites and NAFLD. Causality was estimated using the inverse variance we...

Topics

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• Alcohol Consumption and Health Effects
• Diet, Metabolism, and Disease
• Fatty Liver
• Genome-Wide Association Study
• Immunophenotyping
• Liver Disease Diagnosis and Treatment
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

32382e58-0280-51cb-b9cd-024017e59933

DOI

10.21203/rs.3.rs-3709244/v1