Role of plasma metabolome in mediating the effect of plasma lipidome on NAFLD: a Mendelian randomization study

Abstract excerpt

Background: This study explored the causal connection among the plasma lipidome, nonalcoholic fatty liver disease (NAFLD), and potential metabolome mediators through Mendelian randomization (MR). Methods: = 8,299), and one NAFLD trait from publicly available genome-wide association studies. A two-sample MR analysis was conducted to infer causality. Additionally, multiple sensitivity analyses were conducted to...

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