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Article

Serum metabolites characterize hepatic phenotypes and reveal shared pathways: results from population-based imaging.

Molecular medicine (Cambridge, Mass.) - 21 Jul 2025

Maushagen Juliane, Nattenmüller Johanna, von Krüchten Ricarda, Thorand Barbara, Peters Annette, Rathmann Wolfgang, Adamski Jerzy, Schlett Christopher L, Bamberg Fabian, Wang-Sattler Rui, Rospleszcz Susanne

Abstract excerpt

BACKGROUND: Steatotic liver disease is a major public health issue, with hepatic iron overload exacerbating fibrotic conditions. This study aimed to identify metabolites associated with hepatic fat and/or iron overload using targeted metabolomics in a population-based cohort. METHODS: We used the cross-sectional KORA-MRI study (N = 376 individuals). Hepatic fat and iron content were derived by magnetic resonance...

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Identifiers

PMID: 40691542
DOI: 10.1186/s10020-025-01309-z
PMCID: PMC12282023

Genes

C7

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