Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Causality of blood metabolites on hepatocellular carcinoma and cholangiocarcinoma: a metabolome-wide mendelian randomization study

4 Mar 2025

Abstract excerpt

BACKGROUND: Reportedly, there is an association between body metabolites and the risk of Hepatocellular Carcinoma (HCC) & Cholangiocarcinoma (CCA), possibly due to disrupted metabolic pathways leading to oxidative stress and an imbalance in cell proliferation and apoptosis, thereby increasing the risk of cancer. However, whether metabolites play a role in the onset of HCC or CCA remains inconclusive. OBJECTIVE:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Metabolomics and Mass Spectrometry Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40038628
DOI: 10.1186/s12885-025-13690-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Causality of blood metabolites on hepatocellular carcinoma and cholangiocarcinoma: a metabolome-wide mendelian randomization studyPMID 40038628Read ↗

Mendelian randomization analysis identified serum palmitoylcarnitine as a biomarker for hepatocellular carcinomaSemantic proximity Read ↗

Causal inference of metabolites in autoimmune liver diseases: A Mendelian randomization analysis.Semantic proximity Read ↗

Causal association between 637 human metabolites and ovarian cancer: a mendelian randomization studySemantic proximity Read ↗

Genetically predicted 486 blood metabolites in relation to risk of colorectal cancer: A Mendelian randomization study.Semantic proximity Read ↗

Mendelian randomization identifies 1400 metabolites that may be pathogenic candidates for non-alcoholic fatty liver diseaseSemantic proximity Read ↗

Causal relationship between blood metabolites and inflammatory bowel disease: a metabolome-wide mendelian randomization studySemantic proximity Read ↗

Causal effects of genetically determined metabolites and metabolite ratios on esophageal diseases: a two-sample Mendelian randomization study.Semantic proximity Read ↗

Assessing the causal relationships between human blood metabolites and the risk of NAFLD: A comprehensive mendelian randomization studySemantic proximity Read ↗

The causal relationship between metabolic factors, drinking, smoking and intrahepatic cholangiocarcinoma: a Mendelian randomization studySemantic proximity Read ↗

Causal Effect of Immunocytes, Plasma Metabolites, and Hepatocellular Carcinoma: A Bidirectional Two-Sample Mendelian Randomization Study and Mediation Analysis in East Asian Populations.Semantic proximity Read ↗

Human blood metabolites and risk of severe COVID-19: A Mendelian randomization study.Semantic proximity Read ↗

Exploring blood metabolites and thyroid disorders: a bidirectional mendelian randomization studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.