Article

Reduced activity of nucleus accumbens parvalbumin-expressing fast-spiking inhibitory neurons causes convulsive seizures

2026-03-10

Abstract excerpt

Pathogenic mutations in STXBP1 , which encodes Munc18-1, a synaptic protein essential for synaptic vesicle exocytosis and neurotransmission, and in SCN2A , which encodes the voltage-gated sodium channel Nav1.2 (αII subunit), have been identified in patients with epilepsy. Although haploinsufficiency of either Stxbp1 or Scn2a in cortical excitatory neurons induces epileptic phenotypes in mice and a reduction of...

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Literature Corpus work: 321e4cde-6bd6-518e-9f24-b0c8f375ba43
DOI: 10.64898/2026.03.09.710428

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