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Article

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.

Human molecular genetics - 1 Dec 2013

Ogiwara Ikuo, Iwasato Takuji, Miyamoto Hiroyuki, Iwata Ryohei, Yamagata Tetsushi, Mazaki Emi, Yanagawa Yuchio, Tamamaki Nobuaki, Hensch Takao K, Itohara Shigeyoshi, Yamakawa Kazuhiro

Abstract excerpt

Dravet syndrome is a severe epileptic encephalopathy mainly caused by heterozygous mutations in the SCN1A gene encoding a voltage-gated sodium channel Nav1.1. We previously reported dense localization of Nav1.1 in parvalbumin (PV)-positive inhibitory interneurons in mice and abnormal firing of those neurons in Nav1.1-deficient mice. In the present study, we investigated the physiologic consequence of selective...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23922229
DOI: 10.1093/hmg/ddt331
PMCID: PMC3820136

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Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.PMID 23922229Read ↗

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