Article

Reduction of Nav1.1 in the dorsal striatum preferentially increases hyperthermia-induced generalized seizures compared with the neocortex and nucleus accumbens

2026-05-14

Abstract excerpt

Mutations in SCN1A , which encodes the voltage-gated sodium channel Nav1.1 (αI subunit), are the major cause of Dravet syndrome, a severe developmental and epileptic encephalopathy. Although Nav1.1 haploinsufficiency preferentially impairs inhibitory interneuron function, the region-specific contributions of distributed brain circuits to seizure susceptibility, particularly in subcortical structures that have rec...

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Literature Corpus work: cf16e861-2492-53c5-a42a-0d86f1a64441
DOI: 10.64898/2026.05.11.724427

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