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Article

Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.

Oncotarget - 20 May 2015

Cuyàs Elisabet, Fernández-Arroyo Salvador, Corominas-Faja Bruna, Rodríguez-Gallego Esther, Bosch-Barrera Joaquim, Martin-Castillo Begoña, De Llorens Rafael, Joven Jorge, Menendez Javier A

Abstract excerpt

Metabolic flexibility might be particularly constrained in tumors bearing mutations in isocitrate dehydrogenase 1 (IDH1) leading to the production of the oncometabolite 2-hydroxygluratate (2HG). To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic in...

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Source

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Identifiers

PMID: 25980580
DOI: 10.18632/oncotarget.3733
PMCID: PMC4494938

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25980580-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.PMID 25980580Read ↗

Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production.Semantic proximity Read ↗

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Low pH Facilitates Heterodimerization of Mutant Isocitrate Dehydrogenase IDH1-R132H and Promotes Production of 2-Hydroxyglutarate.Semantic proximity Read ↗

Catalytically distinct metabolic enzyme isocitrate dehydrogenase 1 mutants tune phenotype severity in tumor models.Semantic proximity Read ↗

Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors.Semantic proximity Read ↗

Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells.Semantic proximity Read ↗

Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis.Semantic proximity Read ↗

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