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Single cell multiomics reveal clonal and functional dynamics of MDS stem/progenitor cells during hypomethylating therapy

2026-03-13

Abstract excerpt

Progressive somatic mutations in hematopoietic stem cells (HSCs) drive the development of myelodysplastic neoplasms (MDS). Hypomethylating agents such as azacitidine (AZA) can improve blood counts and reduce blasts, although responses are rarely durable. Determinants of AZA response are complex and incompletely understood, although accumulating evidence suggests that epigenetic rewiring of mutated HSCs underlies i...

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Literature Corpus work
706434bc-1cd2-56e6-9d69-5f655c1eab6c
DOI
10.64898/2026.03.13.711488
Open publication

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Single cell multiomics reveal clonal and functional dynamics of MDS stem/progenitor cells during hypomethylating therapyDOI 10.64898/2026.03.13.711488
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