Nano-genome editors accelerate mRNA cleavage through spatial confinement effect and reverse liver fibrosis by chemogene therapy

Abstract excerpt

<title>Abstract</title> <p>Liver fibrosis is a chronic disease without effective treatment in the clinic. Gene editing systems such as the well-known CRISPR/Cas9 have shown great potential in the biomedical field. However, the delivery of the ribonucleoprotein is challenged by the large size of Cas9 (> 160 kDa) and the instable RNA probe. Recently, a structure-guided endonuclease (SGN) has been reported as an eff...

Topics

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• Advanced biosensing and bioanalysis techniques
• CRISPR and Genetic Engineering
• Innovation and Socioeconomic Development
• Liver Disease Diagnosis and Treatment
• Liver physiology and pathology
• RNA regulation and disease
• Viral gastroenteritis research and epidemiology
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

320e387d-6e6b-5aa6-9969-fd8a377eef84

DOI

10.21203/rs.3.rs-1744036/v1