Article

Yeast Augmented Network Analysis (YANA): a new systems approach to identify therapeutic targets for human genetic diseases

2014-06-02

Abstract excerpt

Genetic interaction networks that underlie most human diseases are highly complex and poorly defined. Better-defined networks will allow identification of a greater number of therapeutic targets. Here we introduce our Y east A ugmented N etwork A nalysis (YANA) approach and test it with the X-linked spinal muscular atrophy (SMA) disease gene UBA1. First, we express UBA1 and a mutant variant in fission yeast...

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Literature Corpus work: 3207127a-6d6b-52ae-9039-87820bff4ef8
DOI: 10.12688/f1000research.4188.1

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