Article
Systematic discovery of nonobvious human disease models through orthologous phenotypes.
Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2010
McGary Kriston L, Park Tae Joo, Woods John O, Cha Hye Ji, Wallingford John B, Marcotte Edward M
Abstract excerpt
Biologists have long used model organisms to study human diseases, particularly when the model bears a close resemblance to the disease. We present a method that quantitatively and systematically identifies nonobvious equivalences between mutant phenotypes in different species, based on overlapping sets of orthologous genes from human, mouse, yeast, worm, and plant (212,542 gene-phenotype associations). These...
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