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Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators

10 Nov 2023

Abstract excerpt

Introduction: Kinesin family member 5A (KIF5A) is a motor neuron protein expressed in neurons and involved in anterograde transportation of organelles, proteins, and RNA. Variations in the KIF5A gene that interfere with axonal transport have emerged as a distinguishing feature in several neurodegenerative disorders, including hereditary spastic paraplegia (HSP10), Charcot-Marie-Tooth disease type 2 (CMT2), and...

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PMID: 38028604
DOI: 10.3389/fgene.2023.1282234

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