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Article

Network analyses reveal novel aspects of ALS pathogenesis.

PLoS genetics - 1 Mar 2015

Sanhueza Mario, Chai Andrea, Smith Colin, McCray Brett A, Simpson T Ian, Taylor J Paul, Pennetta Giuseppa

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective loss of motor neurons, muscle atrophy and paralysis. Mutations in the human VAMP-associated protein B (hVAPB) cause a heterogeneous group of motor neuron diseases including ALS8. Despite extensive research, the molecular mechanisms underlying ALS pathogenesis remain largely unknown. Genetic screens for key...

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Identifiers

PMID: 25826266
DOI: 10.1371/journal.pgen.1005107
PMCID: PMC4380362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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